The Vensim family of software runs on Windows Vista/7/8/8.1/10 (it should also work on Windows XP, but is unsupported). Vensim is a 32 bit program but will run fine on 64 bit versions of Windows. The Macintosh version requires OSX version 10.4 or higher on an Intel processor. The Windows Version will run on the Macintosh using emulators like VMware or Crossover, or with a Windows virtual/alternate boot installation. Vensim requires about 20 megabytes of disk space for a full installation and will run with any reasonable amount of memory. For very large models more memory and disk space will be required as a single run can easily take 100 megabytes of disk space. Generally it is a good idea to have at least as much memory as the size of the largest .vdf file you are creating.
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